Principal Investigator: Dr Pierre Lehmann
Principal Co-Investigator : Dr Jacques Kadoch
Fellow in charge : Dr Chloé Roumain
Sponsor: ovo fertility
Pharmaceutical Funding: Merck
Summary: Recently, scientists have been interested in the G-CSF (Granulocyte – Colony Stimulating Factor) and its used has been increased in reproduction pathologies. The G-CSF, central pivot, would act concomitantly on the ovocyte quality and endometrial receptivity by improving:
> Immunologic tolerance
> Self restoration of chromosome abnormalities in the ovocytes
> Bonding of the embryo to the lining
The purpose of this study is to evaluate the impact of an intra-uterine injection of recombinant G-CSF on pregnancy and implantation rates, during a cycle of IVF-ICSI or during a frozen embryo transfer. This study is intended to women having had 3 or more failed embryo implantation. A repetitive embryo implantation failure is the inability of getting pregnant after 2 to 6 IVF cycles.
Number of participants : 290 participants, recruitment will be done only at the clinique ovo.
Project coordinator : Nelly Delouya – For further information on this study, contact the person in charge of the project at (514) 798-2000 ext 759 or at R-D@cliniqueovo.com.
ClinicalTrials.gov ID : NCT02149277