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Optimo : Expanded combined prenatal
screening with fetal DNA

Screening tests are all based on the measurement of various parameters called markers. These markers indicate the risk of the fetus having certain conditions, such as trisomy 21 or trisomy 18. They can be detected during pregnancy in the maternal blood or on ultrasound. These markers provide reliable results when they are measured at specific times during the pregnancy—some during the first trimester and others during the second trimester.

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    clinique ovo montreal

    All services offered
    8000, boul. Décarie,
    Montreal Qc H4P 2S4

    ovo fertility
    office 100 & 200
    Monday to Friday 7:30am to 6:00pm
    Weekend on appointment
    fertilite@cliniqueovo.com
    ovo elle
    bureau 600
    Monday to Friday 8:00am to 4:00pm
    elle@cliniqueovo.com
    ovo cryo
    Monday to Wed. 8:00am to 5:00pm
    Thursday 8:00am to 6:00pm
    Friday 8:00am to 5:00pm
    Saturday 9:00am to 3:00pm
    Appointments :
    Monday to Friday 9:00am to 3:00pm
    Thursday 9:00am to 4:00pm
    Saturday 9:00am to 2:30pm
    cryo@cliniqueovo.com
    ovo biosurance
    office 600
    Monday to Friday 8:00am to 4:00pm
    biosurance@cliniqueovo.com
    ovo labo
    office 600
    Monday to Friday 8:00am to 4:00pm
    labo@cliniqueovo.com
    ovo prenatal
    office 600
    Monday to Friday 8:00am to 4:00pm
    prenatal@cliniqueovo.com
    ovo r&d
    office 600
    Monday to Friday 7:15am to 5:00pm
    r-d@cliniqueovo.com

    clinique ovo rive-sud

    3141, boul. Taschereau,
    Greenfield Park Qc J4V 2H2

    ovo fertility – certain services offered
    office 410
    Call to know our hours
    fertilite@cliniqueovo.com
    ovo prenatal – certain services offered
    office 420
    Monday to Friday 8:00am to 4:00pm
    prenatal@cliniqueovo.com
    ovo labo – certain services offered
    office 420
    Monday to Friday 8:00am to 4:00pm
    labo@cliniqueovo.com

    clinique ovo quebec

    ovo prenatal – certain services offered
    2600 Boul. Laurier, suite 295,
    Quebec Qc G1V 4T3

    Monday to Friday 8:00am to 4:00pm
    prenatal@cliniqueovo.com



    clinique ovo rive-nord

    ovo prenatal – Prenatal screening
    1000 Montée des Pionniers,
    Terrebonne QC J6V 1S8

    Monday to Thursday 9:00am to 3:00pm
    prenatal@cliniqueovo.com

    clinique Echo-medic

    Ovo prenatal – certain services

    Laval
    1575, boul. de l’Avenir, suite 110,
    Laval Qc H7S 2N5
    t. 1.877.664.3246
    Monday to Thursday 7:30am to 4:30pm
    Friday 7:30am to 3:00pm
    Boisbriand
    20865, chemin de la Côte Nord, suite 201
    Boisbriand Qc J7E 4H5
    t. 1.877.664.3246
    Monday to Thursday 8:00am to 4:00pm
    Friday 8:00am to 3:00pm
    Montreal and South-Shore: t. 514.798.2000
    Quebec: t. 418.425.0128
    f. 514.798.2001
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OPTIMO

optimo is an expanded contingent prenatal screening test designed to assess the risk of your baby being affected by trisomies 21, 18 and 13. The innovative test design combines the advantages of an expanded first-trimester screening with a maternal blood fetal DNA screening test to provide you with highly accurate results early in your pregnancy.

 

logo-optimo

The optimo test indicates the fetus’s risk of having trisomies 18 and 21. The detection rate for trisomy 21 is 98%. This risk is calculated based on the mother’s age, certain ultrasound parameters, and certain hormones and proteins measured in the mother’s blood.

 

The test involves an ultrasound and a blood test done during the first trimester (between 11 and 4/7 weeks and 13 and 6/7 weeks of pregnancy). During the ultrasound, the practitioner will measure nuchal translucency and check for the presence of the nasal bone, elements that will be factored into the risk calculation. The blood test measures the levels of certain hormones and proteins produced by the baby and the placenta, called serum markers, which will also be included in the risk calculation.

 

The expanded optimo test includes more serum markers than other prenatal screening tests currently available on the market. In fact, studies (Nicolaides et al., 2013; Huang et al., 2015) have shown that measuring maternal blood concentrations of AFP and PlGF during the first trimester in addition to the standard markers (PAPP-A, bhCG, nuchal translucency) increases the trisomy 21 detection rate and decreases the false positive rate.

 

Its expanded contingent approach involving fetal DNA screening is the method currently recommended by most major medical associations and colleges worldwide. Several studies have proven that this approach detects trisomies earlier during the pregnancy and decreases the number of patients who require invasive prenatal testing, since the detection and false positive rates are improved (Nicolaides et al., 2013). This approach also retains the benefits of the first-trimester ultrasound and serum markers in terms of dating the pregnancy, and detecting major malformations and certain obstetric complications associated with the serum markers (Nicolaides et al., 2013).

 

The optimo test cannot be performed on twin pregnancies. A fetal DNA screening test will be recommended in these cases.

 

The risk may be low, moderate, or high during the first stage of the optimo prenatal screening test, which consists of the first-trimester ultrasound and blood test. If the risk is low, the screening will end at this stage. If the risk is moderate, a prenatal screening test for fetal DNA in maternal blood will be recommended and is offered free of charge to the patient. In cases where the risk is high, follow-up is done with the referring physician, who may then recommend a prenatal screening test for fetal DNA in maternal blood or prenatal diagnostic testing, depending on the results. In cases where the patient and the doctor opt for a prenatal screening test for fetal DNA in maternal blood, the latter will be offered free of charge to the patient. If the patient and doctor decide to continue with prenatal diagnostic testing (amniocentesis), a FISH test done on the amniotic fluid will be offered free of charge to the patient.

 

In some cases, an invasive prenatal screening test may be strongly recommended and preferable to a fetal DNA test. This may be the case when the factors assessed are associated with chromosomal abnormalities other than those detectable by a fetal DNA test.

 

You will receive your optimo test result by email within three business days. A copy of the results will be sent to your doctor.

 

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